Treating Hypertension with Bonito Fish Peptides

Treating Hypertension with Bonito Fish Peptides

Hypertension (high blood pressure) is a profoundly detrimental health condition experienced by more than 970 million people globally. The World Health Organization (WHO) estimates that by 2020, there will be more than 1.56 billion people worldwide with dangerously elevated blood pressure levels. WHO recognizes hypertension as one of the most prevalent causes of premature human death.

While angiotensin converting enzyme (ACE) inhibitor drugs are prevalently used to treat hypertension, they also cause a variety of undesirable side effects. ACE inhibitors also have a low (34%) success rate in helping people to maintain consistent control of their blood pressure levels. Alternatively, millions are exploring a natural treatment for combating hypertension based on the ingestion of peptides from the Bonita fish.

Hypertension Defined

Hypertension refers to the condition of elevated blood pressure levels, especially the diastolic blood pressure. Hypertension is called the “Silent Killer” because it often presents no noticeable symptoms for years. Because the human body is resilient, it can continue to function for long periods of time before serious damage occurs. However, as the body is having to function with uncontrolled high blood pressure levels, it becomes far more likely to develop coronary heart disease, brain damage, congestive heart failure, stroke, kidney failure, atherosclerosis, vision loss and more.

  • Normal Blood Pressure: Less than 120/80
  • Prehypertension Blood Pressure: 120 – 139/80 – 89
  • Stage 1 Hypertension: 140 -159/90 -99
  • Stage 2 Hypertension: 160 and up/100 and up

Causes of Hypertension

The primary causes of hypertension are the same as the causes for most preventable health conditions:

  • Sedentary lifestyles;
  • High-fat, high-sodium, low-nutrient food intake choices;
  • Being obese;
  • Smoking;
  • Drinking;
  • Being elderly;
  • Stress;
  • Adrenal and/or thyroid disorders;
  • Genetics to a small degree;

In order to understand what causes hypertension on a biochemical level, it’s necessary to understand the relationships between angiotensinogen, angiotensin I and angiotensin II.

Angiotensinogen is a serum protein, comprised of a chain of 452 amino acids, that is manufactured in the liver. Also commonly called angiotensin precursor, angiotensinogen is bonded to renin, an enzyme from the kidneys that digests proteins. When renin cleaves to angiotensinogen, it catalyzes the hydrolysis of angiotensin I.

Angiotensin I is a basically inactive decapeptide and serves only as a precursor to angiotensin II. It is a polypeptide hormone that functions to control arterial pressure within the body. Angiotensin converting enzyme (ACE) is a glycoprotein that acts to convert angiotensin I into angiotensin II by splitting its 2 terminal amino acids. Angiotensin II is a strong vasoconstrictor that causes blood pressure to increase.

What is vasoconstriction?

  • Vasoconstriction means that blood vessels constrict (partially close off).
  • Constricted blood vessels make the heart have to work harder to circulate blood throughout the body.
  • Elevated blood pressure results.

ACE Inhibitors

The most commonly prescribed drugs for treating hypertension are ACE (angiotensin converting enzyme) inhibitors. As their title suggests, ACE inhibitors are effective at stopping the formation of angiotensin converting enzyme. In essence, when angiotensin converting enzyme is present, the conversion of angiotensin I into angiotensin II is inhibited. Less angiotensin II results in less vasoconstriction, and therefore lower blood pressure.

So, in order to stop the conversion of angiotensin, and thereby inhibit the formation of angiotensin II, physicians often prescribe anti-hypertensive ACE inhibitors. These drugs have a relatively low success rate for controlling blood pressure levels, estimated at just 34%. Additionally, ACE inhibitor drugs commonly cause a list of side effects including:

  • Frequent thirst;
  • Craving for salt;
  • Increased release of the steroid hormone called aldosterone which regulates the balance of water and salt levels in the kidneys;
  • Persistent dry coughing;
  • Frequent dizziness;
  • Build up of potassium;
  • Kidney disorders;
  • Headaches;
  • Lightheadedness;
  • Sexual dysfunction;
  • Impotence;

The Bonito Fish

Bioactive Bonito Peptides and Angiotensin II Formation

Peptides are molecules that form when 2 or more amino acids chemically combine. Ongoing research consistently demonstrates that certain peptides, particularly those from the Bonita fish, are very effective at inhibiting the production of angiotensin converting enzyme. This means that carefully extracted bonito fish peptides demonstrate the same benefits of ACE inhibitor drugs, without the negative side effects.

Japanese scientists have developed a patented system for isolating specified active Bonito peptides. These separated amino acid chains have repetitively demonstrated blood pressure reducing effects. Further, scientists from the Research Institute for Food Services at Kyoto University in Tokyo, Japan assert that Bonito proteins may also be very helpful in lowering cholesterol levels.

**Note that bonito peptides should not be confused with much more commonly used fish oils.**

Clinical Human Research Results

Research on blood pressure reduction via Bonito peptide therapy is based on a broader thesis that certain bioactive peptides are able to prevent and/or reverse certain health conditions, especially if the conditions are caused by lifestyle choices. Specifically, 9 active bonito fish peptides have been identified and consistently shown to have strong blood pressure lowering effects, especially in individuals with borderline to mild hypertensive conditions.

Several human trials have been completed that address the blood pressure lowering properties of bonito fish peptides. The cumulative data gathered from these double-blind, randomized, crossover studies supports the following:
  • Approximately 2/3 of borderline or mildly hypertensive persons experienced significant blood pressure lowering effects when engaged in bonito fish peptide therapy. This is especially impressive when compared to the relatively low success rate of 34% associated with mass-prescribed ACE inhibitor drugs.
  • Bonito fish peptide therapy typically reduces systolic pressure by 10 mm Hg while simultaneously reducing diastolic pressure by 7 mm Hg.
  • One point five (1.5) grams per day of bonito peptides are considered an optimal amount for the effective treatment of hypertension.
  • No side effects have been observed or reported concerning bonito peptide therapy for the treatment of high blood pressure.
  • Bonito peptides will not reduce the blood pressure of individuals with normal blood pressure.
  • With abrupt bonito peptide therapy termination, no reverse effects, no rebound effects and no abnormally high blood pressure resulted.

Ongoing clinical research continues to strongly support that bonito fish bioactive peptides are more beneficial for the treatment of hypertension than are ACE inhibitor drugs. Further, they demonstrate no adverse side effects. Because the peptides are naturally strong vasodilators, they are the targets of any angiotensin converting enzymes that may be present. With the peptides taking the attention of the ACE, angiotensin II is prevented from being produced. The result is a relaxation (dilation) of the vascular system, and in turn, reduced blood pressure.

What Every Human Needs

With the streamlined techniques and products of modern allopathic medicinal systems so globally prevalent, people are left with many questions about what’s really best for their health. Obviously, there is widespread interest in the discovery and implementation of alternative, holistic therapies. Regardless of the most modern health trends and treatments, all humans will benefit immeasurably from:

  • Maintaining a food intake program based primarily on water-rich, low-fat, low-sodium sources like vegetables, fruits, beans, legumes and sprouts;
  • Avoiding food sources that are deep fried, fried, packaged, pre-prepared, preserved and/or genetically modified;
  • Remaining hydrated and flushing regularly with crisp, clean water;
  • Engaging in semi-strenuous physical activity on a daily basis;
  • Managing stress levels consistently and effectively;

Globally, hundreds of millions of people are looking for natural alternatives to pharmaceutical remedies for prevalent health conditions, like hypertension. When individuals take primary responsibility for their health by permanently implementing holistic lifestyle modifications, they significantly increase their probabilities of remaining vibrant as they age. Also, when the human body is more naturally healthy, allopathic and other medicinal approaches for healing will be more effective. Living healthy and long is all about being accountable for choices made, exploring alternative healing methods, like bonito fish bioactive peptides – and taking advantage of the most modern medical advancements.